El equipo de IrsiCaixa en el laboratorio.<\/summary>\n – IRSICAIXA<\/figcaption><\/div>\n
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BARCELONA, 8 Abr. (EUROPA PRESS) – <\/p>\n
Un estudio liderado por IrsiCaixa ha descrito por primera vez en profundidad las alteraciones inmunitarias asociadas al Covid persistente pedi\u00e1trico, revelando una desregulaci\u00f3n de la primera l\u00ednea de defensa contra el virus y una menor capacidad de generar anticuerpos.<\/p>\n
El trabajo, publicado en la revista cient\u00edfica ‘JCI Insight’, ha analizado diferentes marcadores y ha demostrado que la mol\u00e9cula CCR6 se expresa de forma \u00abclaramente distinta\u00bb entre los ni\u00f1os con y sin la condici\u00f3n, situ\u00e1ndola como posible marcador biol\u00f3gico de la enfermedad, informa IrsiCaixa en un comunicado de este mi\u00e9rcoles.<\/p>\n
La investigadora asociada de IrsiCaixa y l\u00edder del proyecto, Sara Mor\u00f3n-L\u00f3pez, ha apuntado que conocer las alteraciones inmunitarias asociadas al Covid persistente permite \u00abempezar a pensar en estrategias para revertirlas y, potencialmente, tratar esta condici\u00f3n\u00bb.<\/p>\n
METODOLOG\u00cdA<\/h2>\n
La investigaci\u00f3n se ha llevado a cabo en el marco de la cohorte pediaCovid del Hospital Germans Trias i Pujol de Badalona (Barcelona), e incluy\u00f3 a 99 menores con Covid persistente y 18 que no presentaban la condici\u00f3n.<\/p>\n
Todos ellos fueron evaluados 3 meses despu\u00e9s de la infecci\u00f3n aguda por Sars-CoV-2, con un estudio en profundidad de su sistema inmunitario a partir de muestras de sangre.<\/p>\n
RESULTADOS<\/h2>\n
Los resultados muestran que los ni\u00f1os con Covid persistente presentan una alteraci\u00f3n de la inmunidad innata, la primera l\u00ednea de defensa contra el virus y la que coordina y activa el resto de respuestas.<\/p>\n
Seg\u00fan el equipo investigador, esta desregulaci\u00f3n podr\u00eda estar afectando a la respuesta adaptativa, la m\u00e1s espec\u00edfica contra el Sars-CoV-2.<\/p>\n
El investigador predoctoral en IrsiCaixa y primer autor del art\u00edculo, Jon Izquierdo-Pujol, ha apuntado que uno de los resultados \u00abm\u00e1s relevantes\u00bb es que los j\u00f3venes presentan niveles m\u00e1s bajos de anticuerpos con capacidad neutralizante, es decir, capaces de bloquear el virus de forma efectiva.<\/p>\n
MOL\u00c9CULA CCR6<\/h2>\n
Mediante modelos computacionales que integraban todos los par\u00e1metros inmunol\u00f3gicos analizados, el equipo identific\u00f3 la mol\u00e9cula CCR6 como el factor con mayor capacidad para diferenciar los dos grupos.<\/p>\n
Los ni\u00f1os con Covid persistente mostraban una menor expresi\u00f3n de esta mol\u00e9cula, \u00abfundamental\u00bb para dirigir las c\u00e9lulas inmunitarias hacia el lugar de la infecci\u00f3n y coordinar una respuesta adecuada.<\/p>\n
En el modelo predictivo desarrollado por el equipo, CCR6 permiti\u00f3 identificar los casos con una precisi\u00f3n del 79%, un resultado que lo sit\u00faa como \u00abposible biomarcador objetivo\u00bb para ayudar en el diagn\u00f3stico, que actualmente se basa principalmente en criterios cl\u00ednico.<\/p>\n","protected":false},"excerpt":{"rendered":"
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