{"id":110898,"date":"2026-04-08T16:23:13","date_gmt":"2026-04-08T16:23:13","guid":{"rendered":"http:\/\/acc4863f1bef452fe2627928f997a743"},"modified":"2026-04-08T16:23:13","modified_gmt":"2026-04-08T16:23:13","slug":"un-estudio-establece-un-nuevo-modelo-para-entender-el-origen-del","status":"publish","type":"post","link":"https:\/\/sarmiento24h.com\/?p=110898","title":{"rendered":"Un estudio establece un nuevo modelo para entender el origen del…"},"content":{"rendered":"

<\/p>\n

\n<\/p>\n
\n\"El<\/div>\n


\n<\/p>\n

\nEl equipo a cargo del estudio.<\/summary>\n

– UB<\/figcaption><\/div>\n

\n<\/div>\n

<\/p>\n

BARCELONA 8 Abr. (EUROPA PRESS) – <\/p>\n

Un estudio liderado por la Universitat de Barcelona (UB) ha establecido un modelo de dos fases para entender el origen de la leucemia linfobl\u00e1stica aguda de c\u00e9lulas B (LLA-B) pedi\u00e1trica, el c\u00e1ncer infantil m\u00e1s frecuente, contribuyendo al dise\u00f1o de estrategias de prevenci\u00f3n de la enfermedad.<\/p>\n

El trabajo, publicado en la revista ‘Cell Reports, revela que la inestabilidad cromos\u00f3mica caracter\u00edstica de este c\u00e1ncer reduce la proliferaci\u00f3n de las c\u00e9lulas afectadas, retrasa su diferenciaci\u00f3n y facilita que pueda persistir como clones raros y duradores en la m\u00e9dula \u00f3sea, pero sin desencadenar la leucemia, informa la UB en un comunicado de este mi\u00e9rcoles.<\/p>\n

El art\u00edculo plantea un modelo en dos fases para entender el origen de la leucemia: un primer episodio prenatal –la hiperdiploidia– y un segundo paso posnatal –causado por factores desconocidos–, necesario para iniciar la transformaci\u00f3n maligna de los clones raros y desarrollar la enfermedad.<\/p>\n

Entre la primera fase y la segunda podr\u00eda haber una ventana temporal \u00abde entre 2 y 6 a\u00f1os\u00bb, que se corresponde con el pico de incidencia m\u00e1s alto de las leucemias linfobl\u00e1sticas infantiles, si bien todav\u00eda es una inc\u00f3gnita c\u00f3mo estos clones raros evolucionan para causar la enfermedad.<\/p>\n

Los cromosomas ganados en los clones en modelos animales coinciden con los m\u00e1s frecuentes de LLA-B, lo que \u00abrefuerza la relevancia cl\u00ednica\u00bb del modelo y sugiere que estas ganancias gen\u00e9ticas pueden contribuir a la presencia de las c\u00e9lulas preleuc\u00e9micas.<\/p>\n","protected":false},"excerpt":{"rendered":"

El equipo a cargo del estudio. – UB BARCELONA 8 Abr. (EUROPA PRESS) – Un estudio liderado por la Universitat de Barcelona (UB) ha establecido un modelo de dos fases para entender el origen de la leucemia linfobl\u00e1stica aguda de c\u00e9lulas B (LLA-B) pedi\u00e1trica, el c\u00e1ncer infantil m\u00e1s frecuente, contribuyendo al dise\u00f1o de estrategias de […]<\/p>\n","protected":false},"author":1,"featured_media":110899,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[64],"tags":[],"class_list":["post-110898","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud"],"yoast_head":"\nUn estudio establece un nuevo modelo para entender el origen del... - Sarmiento24h<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sarmiento24h.com\/?p=110898\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un estudio establece un nuevo modelo para entender el origen del... - Sarmiento24h\" \/>\n<meta property=\"og:description\" content=\"El equipo a cargo del estudio. – UB BARCELONA 8 Abr. 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