Archivo – Imagen de recurso de esperma.<\/summary>\n – UGURHAN\/ ISTOCK – Archivo<\/figcaption><\/div>\n
\n<\/div>\n
<\/p>\n
MADRID 8 Abr. (EUROPA PRESS) – <\/p>\n
Un nuevo estudio de la Universidad de Cornell (EEUU) en ratones, realizado durante seis a\u00f1os, ha demostrado que la activaci\u00f3n de un punto de control natural en la meiosis -el proceso por el que se forman las c\u00e9lulas sexuales- puede detener de forma segura la producci\u00f3n de esperma.<\/p>\n
En el estudio, publicado en ‘Proceedings of the National Academy of Sciences’, los investigadores utilizaron JQ1, un inhibidor de mol\u00e9cula peque\u00f1a desarrollado como herramienta de investigaci\u00f3n para el estudio del c\u00e1ncer y las enfermedades inflamatorias. Debido a sus efectos secundarios neurol\u00f3gicos, no era una terapia viable para la enfermedad ni un m\u00e9todo anticonceptivo definitivo, pero se sabe que interrumpe una etapa de la meiosis llamada profase 1. Esto permiti\u00f3 a los investigadores de Cornell proporcionar la primera prueba de concepto de que la meiosis -y la producci\u00f3n de esperma- pueden ser atacadas de forma segura y reversible.<\/p>\n
\u00abSomos pr\u00e1cticamente el \u00fanico grupo que impulsa la idea de que los objetivos anticonceptivos en los test\u00edculos son una forma viable de detener la producci\u00f3n de esperma\u00bb, ha afirmado Paula Cohen, profesora de gen\u00e9tica y directora del Centro de Ciencias Reproductivas de Cornell.<\/p>\n
\u00abNuestro estudio demuestra que, en la mayor\u00eda de los casos, recuperamos la meiosis normal y la funci\u00f3n completa del esperma, y ??lo que es m\u00e1s importante, que la descendencia es completamente normal\u00bb, ha a\u00f1adido Cohen.<\/p>\n
Actualmente, los anticonceptivos masculinos incluyen condones y vasectom\u00edas. Por el momento la vasectom\u00eda es la \u00fanica opci\u00f3n de larga duraci\u00f3n disponible, y que t\u00e9cnicamente es reversible mediante cirug\u00eda posterior. Los investigadores se han mostrado especialmente reacios a desarrollar un anticonceptivo hormonal, ya que estos tratamientos han demostrado ser potencialmente peligrosos para las mujeres.<\/p>\n
Cohen y sus colegas decidieron centrarse en la meiosis, en lugar de en otras etapas, para detener por completo la producci\u00f3n de esperma de forma reversible y sin afectar la funcionalidad de los dem\u00e1s \u00f3rganos reproductores masculinos. \u00abNo quer\u00edamos afectar las c\u00e9lulas madre espermatogoniales, porque si se destruyen, un hombre nunca volver\u00e1 a ser f\u00e9rtil. Adem\u00e1s, una vez que el esperma entra en la espermiog\u00e9nesis, existe la posibilidad de que espermatozoides viables se filtren y fecunden un \u00f3vulo\u00bb, ha explicado Cohen.<\/p>\n
RECUPERARON LA PRODUCCI\u00d3N NORMAL DE ESPERMA<\/h2>\n
El JQ1 interrumpe la meiosis al destruir c\u00e9lulas durante la profase I e impide el inicio de la expresi\u00f3n g\u00e9nica necesaria para la espermiog\u00e9nesis. En el estudio, los investigadores administraron JQ1 a ratones macho durante tres semanas. Descubrieron que los ratones no produc\u00edan esperma y que todos los par\u00e1metros moleculares de la meiosis estaban alterados, incluido el comportamiento cromos\u00f3mico durante la profase 1.<\/p>\n
Luego dejaron de administrar JQ1 y, en seis semanas, la mayor\u00eda de los par\u00e1metros normales de la profase 1 se recuperaron, junto con la producci\u00f3n normal de esperma. Posteriormente, cruzaron a esos ratones y comprobaron que todos eran f\u00e9rtiles. Al cruzar a las cr\u00edas, demostraron que tambi\u00e9n eran f\u00e9rtiles y que ten\u00edan descendencia sana.<\/p>\n
\u00abEsto demuestra que recuperamos la meiosis completa, la funci\u00f3n esperm\u00e1tica completa y, lo que es m\u00e1s importante, que la descendencia es completamente normal. Un anticonceptivo masculino probablemente comenzar\u00eda con una inyecci\u00f3n cada tres meses, o posiblemente un parche, para garantizar su eficacia\u00bb, ha finalizado Cohen.<\/p>\n","protected":false},"excerpt":{"rendered":"
Archivo – Imagen de recurso de esperma. – UGURHAN\/ ISTOCK – Archivo MADRID 8 Abr. (EUROPA PRESS) – Un nuevo estudio de la Universidad de Cornell (EEUU) en ratones, realizado durante seis a\u00f1os, ha demostrado que la activaci\u00f3n de un punto de control natural en la meiosis -el proceso por el que se forman las […]<\/p>\n","protected":false},"author":1,"featured_media":111064,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[64],"tags":[],"class_list":["post-111063","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud"],"yoast_head":"\n
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