{"id":111389,"date":"2026-04-08T22:51:50","date_gmt":"2026-04-08T22:51:50","guid":{"rendered":"http:\/\/5a148050bc733807d287576bdf9105c9"},"modified":"2026-04-08T22:51:50","modified_gmt":"2026-04-08T22:51:50","slug":"un-hallazgo-sobre-el-cancer-apunta-a-una-posible-terapia-comun-para","status":"publish","type":"post","link":"https:\/\/sarmiento24h.com\/?p=111389","title":{"rendered":"Un hallazgo sobre el c\u00e1ncer apunta a una posible terapia com\u00fan para…"},"content":{"rendered":"

<\/p>\n

\n<\/p>\n
\n\"Archivo<\/div>\n


\n<\/p>\n

\nArchivo – Laboratorio.<\/summary>\n

– XUBINGRUO\/ ISTOCK – Archivo<\/figcaption><\/div>\n

\n<\/div>\n

<\/p>\n

   MADRID, 8 Abr. (EUROPA PRESS) – <\/p>\n

    Un nuevo estudio precl\u00ednico internacional liderado por el Centro Nacional de C\u00e1ncer Dharshini Subbiah de Singapur (NCCS) ha identificado dos prote\u00ednas que pueden impulsar el crecimiento de diversos tipos de c\u00e1ncer al alterar un mecanismo supresor de tumores, y muestra que la inhibici\u00f3n de estas prote\u00ednas puede reducir los tumores y prolongar la supervivencia en ratones. <\/p>\n

Aunque a\u00fan es preliminar,<\/strong> este trabajo representa un paso importante hacia una terapia panc\u00e1ncer para tumores deficientes en el supresor tumoral BAP1, tal y como se recoge en ‘Science’.<\/a><\/p>\n

EL FALLO COM\u00daN QUE COMPARTEN VARIOS TIPOS DE C\u00c1NCER<\/strong><\/p>\n

   Muchos tipos de c\u00e1ncer pueden presentar mutaciones en BAP1, incluyendo el colangiocarcinoma, el mesotelioma y el c\u00e1ncer de h\u00edgado. Estas mutaciones desactivan las propiedades supresoras de tumores de la prote\u00edna, impulsando as\u00ed la proliferaci\u00f3n y la agresividad de las c\u00e9lulas cancerosas. Sin embargo, la mayor\u00eda de los estudios previos sobre BAP1 se han centrado en tipos espec\u00edficos de c\u00e1ncer<\/strong>, por lo que existe una escasez de investigaci\u00f3n sobre los mecanismos y las vulnerabilidades terap\u00e9uticas compartidas entre los c\u00e1nceres que presentan mutaciones en BAP1.<\/p>\n

    Para subsanar esta deficiencia, los investigadores utilizaron una t\u00e9cnica de \u00abpulldown\u00bb combinada con espectrometr\u00eda de masas para mapear el panorama de las prote\u00ednas que BAP1 desubiquitina, una modificaci\u00f3n bioqu\u00edmica que implica la eliminaci\u00f3n de grupos ubiquitina. Este an\u00e1lisis revel\u00f3 que BAP1 potencia un mecanismo de protecci\u00f3n del ADN denominado reparaci\u00f3n por escisi\u00f3n de nucle\u00f3tidos del genoma global. El cribado farmacol\u00f3gico tambi\u00e9n revel\u00f3 que dos prote\u00ednas, LSD1 y PARP1, interact\u00faan con BAP1 y se localizan junto al supresor tumoral en la cromatina.<\/p>\n

    Posteriormente, los investigadores descubrieron que la inhibici\u00f3n de LSD1 y PARP1 mediante un compuesto experimental y el inhibidor de PARP aprobado, olaparib, respectivamente, provocaba la muerte de las c\u00e9lulas cancerosas, reduc\u00eda el tama\u00f1o de los tumores y prolongaba la supervivencia en ratones con tumores deficientes en <\/strong>BAP1. <\/p>\n

   Adem\u00e1s, se\u00f1alan que su estudio est\u00e1 limitado por su naturaleza precl\u00ednica y solicitan m\u00e1s investigaci\u00f3n para evaluar la aplicabilidad traslacional de su estrategia.<\/p>\n","protected":false},"excerpt":{"rendered":"

Archivo – Laboratorio. – XUBINGRUO\/ ISTOCK – Archivo    MADRID, 8 Abr. (EUROPA PRESS) –     Un nuevo estudio precl\u00ednico internacional liderado por el Centro Nacional de C\u00e1ncer Dharshini Subbiah de Singapur (NCCS) ha identificado dos prote\u00ednas que pueden impulsar el crecimiento de diversos tipos de c\u00e1ncer al alterar un mecanismo supresor de tumores, y muestra […]<\/p>\n","protected":false},"author":1,"featured_media":111390,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[64],"tags":[],"class_list":["post-111389","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud"],"yoast_head":"\nUn hallazgo sobre el c\u00e1ncer apunta a una posible terapia com\u00fan para... - Sarmiento24h<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sarmiento24h.com\/?p=111389\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un hallazgo sobre el c\u00e1ncer apunta a una posible terapia com\u00fan para... - Sarmiento24h\" \/>\n<meta property=\"og:description\" content=\"Archivo – Laboratorio. – XUBINGRUO\/ ISTOCK – Archivo    MADRID, 8 Abr. 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