Archivo – Fachada de la Facultad de Ciencias Qu\u00edmicas de la Universidad Complutense de Madrid (UCM), a 3 de mayo de 2024, en Madrid (Espa\u00f1a). La Facultad de Ciencias Qu\u00edmicas de la UCM se fund\u00f3 en 1974 como consecuencia de la separaci\u00f3n de la Facultad de <\/summary>\n – Jes\u00fas Hell\u00edn – Europa Press – Archivo<\/figcaption><\/div>\n
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MADRID, 9 Abr. (EUROPA PRESS) – <\/p>\n
Un equipo de investigadores de la Universidad Complutense de Madrid (UCM), en colaboraci\u00f3n con cient\u00edficos del Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias y del Center for Cooperative Research in Biomaterials, ha demostrado que la activaci\u00f3n de la prote\u00edna receptor sigma-1 mejora el funcionamiento del coraz\u00f3n y de los vasos sangu\u00edneos del pulm\u00f3n en un modelo animal de hipertensi\u00f3n arterial pulmonar.<\/p>\n
El estudio, publicado en Biomed Pharmacother, mostr\u00f3 como la activaci\u00f3n del receptor sigma-1 era capaz de reducir la contracci\u00f3n excesiva de las arterias pulmonares, mejorar la funci\u00f3n del ventr\u00edculo derecho del coraz\u00f3n, que es el encargado de bombear sangre hacia los pulmones, y atenuar el da\u00f1o estructural en el coraz\u00f3n y en los vasos pulmonares caracter\u00edstico de la enfermedad.<\/p>\n
En conjunto, estos efectos contribuyeron a ralentizar la progresi\u00f3n de esta grave y poco frecuente enfermedad en el modelo experimental utilizado, seg\u00fan ha detallado la Unidad de Cultura Cient\u00edfica de la Complutense en un comunicado.<\/p>\n
\u00abHasta ahora, la mayor\u00eda de los medicamentos disponibles para la hipertensi\u00f3n arterial pulmonar actuaban sobre otros procesos del organismo. Encontrar nuevas dianas terap\u00e9uticas, es decir nuevos mecanismos sobre los que actuar con medicamentos, es esencial para seguir avanzando\u00bb, ha destacado el investigador del equipo y miembro del Departamento de Farmacolog\u00eda y Toxicolog\u00eda de la UCM Daniel Morales.<\/p>\n
Para llevar a cabo el estudio, los investigadores utilizaron un modelo experimental de la enfermedad en roedores que reproduce muchas de las caracter\u00edsticas que se observan en pacientes. En este modelo, los animales desarrollan un aumento de la presi\u00f3n pulmonar y el ventr\u00edculo derecho del coraz\u00f3n comienza a sufrir las consecuencias de ese esfuerzo extra. Durante varias semanas, los investigadores administraron el activador de Sigma-1, PRE084 y observaron la mejor\u00eda descrita.<\/p>\n
\u00abLos experimentos se han realizado en modelos animales y todav\u00eda es necesario realizar m\u00e1s estudios para confirmar los resultados y entender mejor c\u00f3mo funciona este mecanismo\u00bb, ha recordado el investigador principal del estudio \u00c1ngel Cogolludo.<\/p>\n
PROBAR LA NUEVA DIANA<\/h2>\n
El siguiente paso en esta l\u00ednea de investigaci\u00f3n ser\u00e1 probar esta nueva diana utilizando f\u00e1rmacos ya comercializados que act\u00faen sobre ella en modelos animales, con el objetivo de analizar su eficacia y seguridad en condiciones m\u00e1s cercanas a las humanas.<\/p>\n
\u00abEn caso de que las investigaciones futuras confirman estos resultados, este enfoque podr\u00eda abrir la puerta al desarrollo de nuevas terapias para la hipertensi\u00f3n arterial pulmonar, una enfermedad que todav\u00eda supone un gran desaf\u00edo para la medicina\u00bb, han se\u00f1alado los investigadores del grupo de la UCM.<\/p>\n
Este trabajo ha sido posible gracias al apoyo de diferentes organismos de financiaci\u00f3n de la investigaci\u00f3n, entre ellos el Ministerio de Ciencia e Innovaci\u00f3n y la Agencia Estatal de Investigaci\u00f3n (PID2020-117939RB-I00), el Instituto de Salud Carlos III, la Comunidad de Madrid, la Fundaci\u00f3n contra la Hipertensi\u00f3n Pulmonar (Empathy) y programas europeos como Marie Sklodowska-Curie, cuyo apoyo resulta fundamental para seguir impulsando avances cient\u00edficos en enfermedades complejas.<\/p>\n","protected":false},"excerpt":{"rendered":"
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