Remodelado hep\u00e1tico y progresi\u00f3n de la enfermedad en modelos de h\u00edgado graso – Im\u00e1genes adaptadas de Belloc et al., ‘Science Advances’ (2026).<\/summary>\n – IRB BARCELONA<\/p><\/div>\n
<\/div>\n
<\/p>\n
BARCELONA 9 Abr. (EUROPA PRESS) – <\/p>\n
Un estudio liderado por investigadores del IRB Barcelona y del Hospital Cl\u00ednic-IDIBAPS ha identificado un nuevo mecanismo que explica c\u00f3mo se regular la producci\u00f3n de prote\u00ednas en el h\u00edgado graso bajo estr\u00e9s metab\u00f3lico, informa el IRB en un comunicado este jueves.<\/p>\n
Publicado en ‘Science Advances’, afirma que el 70% de la respuesta celular al estr\u00e9s metab\u00f3lico se regula en la traducci\u00f3n del ARN mensajero, un nivel de control que \u00abredefine\u00bb la interpretaci\u00f3n de la reprogramaci\u00f3n de la expresi\u00f3n g\u00e9nica asociada a enfermedades hep\u00e1ticas.<\/p>\n
El equipo combin\u00f3 enfoques experimentales en modelos animales de estr\u00e9s metab\u00f3lico con datos de pacientes y an\u00e1lisis computacionales integrando distintos abordajes \u00f3micos: esta metodolog\u00eda permiti\u00f3 mapear por primera vez el desajuste entre los mensajes gen\u00e9ticos (ARN) y su producto final (prote\u00ednas).<\/p>\n
El estudio muestra que la prote\u00edna CPEB4 act\u00faa como un regulador central que ajusta qu\u00e9 mensajes se traducen en cada momento, \u00abpermitiendo a las c\u00e9lulas ajustar su funcionamiento en condiciones adversas\u00bb.<\/p>\n
Estos mecanismos no solo permiten a las c\u00e9lulas adaptarse al estr\u00e9s, sino que tambi\u00e9n est\u00e1n relacionados con la progresi\u00f3n del h\u00edgado graso hacia formas m\u00e1s graves, como la inflamaci\u00f3n, la fibrosis o el c\u00e1ncer de h\u00edgado.<\/p>\n
El proyecto se inici\u00f3 con la financiaci\u00f3n de la Fundaci\u00f3n La Caixa y se ha desarrollado y completado con el respaldo de la AECC; y tambi\u00e9n ha recibido financiaci\u00f3n de la Marat\u00f3 de TV3, la Fundaci\u00f3n BBVA, Worldwide Cancer Research, el Ministerio de Ciencia, Innovaci\u00f3n y Universidades y la Generalitat, as\u00ed como del Instituto de Salud Carlos III y la Comisi\u00f3n Europea. <\/p>\n","protected":false},"excerpt":{"rendered":"
Remodelado hep\u00e1tico y progresi\u00f3n de la enfermedad en modelos de h\u00edgado graso – Im\u00e1genes adaptadas de Belloc et al., ‘Science Advances’ (2026). – IRB BARCELONA BARCELONA 9 Abr. (EUROPA PRESS) – Un estudio liderado por investigadores del IRB Barcelona y del Hospital Cl\u00ednic-IDIBAPS ha identificado un nuevo mecanismo que explica c\u00f3mo se regular la producci\u00f3n […]<\/p>\n","protected":false},"author":1,"featured_media":112939,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[64],"tags":[],"class_list":["post-112938","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud"],"yoast_head":"\n
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