Las alteraciones en los queratinocitos pueden provocar afecciones inflamatorias de la piel<\/strong>, como psoriasis, eccema e hidradenitis supurativa. Investigaciones recientes tambi\u00e9n han relacionado estos trastornos con cambios en la comunicaci\u00f3n molecular entre los queratinocitos y el sistema inmunitario.<\/p>\n Algunos estudios han sugerido que la familia de prote\u00ednas de queratina modula esta comunicaci\u00f3n de diversas maneras, pero no estaba claro c\u00f3mo una alteraci\u00f3n en la se\u00f1alizaci\u00f3n de las prote\u00ednas de queratina podr\u00eda desencadenar una enfermedad inflamatoria de la piel. En este estudio, los investigadores se centraron en una prote\u00edna de queratina llamada queratina 16. Eligieron esta prote\u00edna porque las mutaciones en su gen correspondiente (KRT16) causan PC, que produce callosidades dolorosas y severas, as\u00ed como u\u00f1as inusualmente gruesas.<\/p>\n
El equipo examin\u00f3 lesiones de pacientes con PC y observ\u00f3 evidencia de una se\u00f1alizaci\u00f3n de interfer\u00f3n tipo I inusualmente activa, una v\u00eda inmunitaria inflamatoria. Confirmaron esta conexi\u00f3n en queratinocitos humanos y de rat\u00f3n ex vivo que carec\u00edan de KRT16 y descubrieron que la eliminaci\u00f3n de Krt16 en ratones reclutaba neutr\u00f3filos a la piel y desencadenaba una enfermedad similar a la psoriasis. <\/p>\n
EL HALLAZGO QUE ABRE LA PUERTA A NUEVOS TRATAMIENTOS<\/h2>\n
Sin embargo, la aplicaci\u00f3n del medicamento aprobado ruxolitinib en forma de crema a ratones<\/strong> que carec\u00edan de Krt16 calm\u00f3 la inflamaci\u00f3n de la piel y disminuy\u00f3 la gravedad de las lesiones. \u00abEstos hallazgos son importantes para una mejor comprensi\u00f3n de las enfermedades inflamatorias cr\u00f3nicas de la piel y para explorar enfoques terap\u00e9uticos previamente desconocidos para la PC\u00bb, concluyen los expertos.<\/p>\n","protected":false},"excerpt":{"rendered":"Archivo – CLOSE UP: Unrecognizable young woman suffering from autoimmune incurable dermatological skin disease called psoriasis. Female gently scratching red, inflamed, scaly rash on elbows. Psoriatic arthritis – HELIVIDEO\/ ISTOCK – Archivo MADRID, 9 Abr. (EUROPA PRESS) – Un nuevo estudio de la Facultad de Medicina de la Universidad de Michigan (Estados Unidos) revela c\u00f3mo […]<\/p>\n","protected":false},"author":1,"featured_media":113130,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"content-type":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[64],"tags":[],"class_list":["post-113129","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud"],"yoast_head":"\n
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