{"id":200670,"date":"2026-05-12T15:11:13","date_gmt":"2026-05-12T15:11:13","guid":{"rendered":"http:\/\/6a0338d2b3bb94a04389faba"},"modified":"2026-05-12T15:11:13","modified_gmt":"2026-05-12T15:11:13","slug":"hay-una-forma-mejor-de-medir-el-colesterol-malo","status":"publish","type":"post","link":"https:\/\/sarmiento24h.com\/?p=200670","title":{"rendered":"Hay una forma mejor de medir el \u00abcolesterol malo\u00bb"},"content":{"rendered":"
<\/div>\n

Investigaciones m\u00e1s recientes sugieren que el panorama del colesterol es m\u00e1s complejo, sobre todo en personas que ya toman estatinas. Estudios anteriores dirigidos por Nordestgaard han demostrado que, en los pacientes tratados, los niveles elevados de apolipoprote\u00edna B y colesterol no HDL siguen estando asociados a un mayor riesgo de infarto de miocardio y mortalidad, mientras que el colesterol LDL no. La apoB, en particular, se revel\u00f3 como el marcador m\u00e1s preciso.<\/p>\n

Para Kausik Ray, cardi\u00f3logo del Imperial College de Londres, el reto no es elegir un marcador en lugar de otro, sino entender qu\u00e9 capta cada uno y qu\u00e9 pasa por alto.<\/p>\n

\u00abNo nos interesa el colesterol porque s\u00ed\u00bb, aclara Ray. \u00abIntentamos prevenir infartos de miocardio y accidentes cerebrovasculares\u00bb.<\/p>\n

El colesterol entra en las paredes arteriales a trav\u00e9s de part\u00edculas que contienen apoB, pero esas part\u00edculas no son todas iguales. Las LDL constituyen la mayor parte de ellas, pero la lipoprote\u00edna(a) y las part\u00edculas ricas en triglic\u00e9ridos tambi\u00e9n desempe\u00f1an un papel. La apoB capta el n\u00famero total, pero no su origen.<\/p>\n

\u00abTener una apoB muy alta captar\u00e1 a m\u00e1s personas que solo las LDL\u00bb, explica Ray. \u00abPero lo que se haga al respecto es otra cuesti\u00f3n\u00bb.<\/p>\n

Una apoB elevada podr\u00eda ser impulsada por diferentes problemas subyacentes (alto LDL, resistencia a la insulina, obesidad o factores gen\u00e9ticos) y cada uno podr\u00eda requerir una intervenci\u00f3n diferente.<\/p>\n

\u00abSi s\u00f3lo tuvieras apoB, no sabes si centrarte en la reducci\u00f3n del LDL o en la p\u00e9rdida de peso o en el control de la glucosa\u00bb, expresa Ray.<\/p>\n

Ah\u00ed es donde entran los matices. La apoB puede ser una mejor se\u00f1al global de riesgo, pero los m\u00e9dicos a\u00fan necesitan entender qu\u00e9 la impulsa. \u00abPorque entonces se puede personalizar\u00bb, comenta Ray.<\/p>\n

Esa necesidad de una imagen m\u00e1s detallada ya est\u00e1 impulsando las pruebas de colesterol m\u00e1s all\u00e1 de una sola cifra. Tanto Ray como Nordestgaard se\u00f1alan la lipoprote\u00edna (a), una forma de colesterol determinada gen\u00e9ticamente que rara vez se mide, pero que puede aumentar significativamente el riesgo.<\/p>\n

\u00abEn el Reino Unido tenemos un problema enorme: menos del 5% de la poblaci\u00f3n se somete a las pruebas\u00bb, afirma Ray. \u00abSolo hay que medir la lipoprote\u00edna(a) una vez en la vida\u00bb.<\/p>\n

Hoy ser\u00eda distinto<\/h2>\n

Nordestgaard argumenta que si las pruebas de l\u00edpidos se dise\u00f1aran desde cero hoy en d\u00eda, no se centrar\u00edan en una sola medida en absoluto.<\/p>\n

\u00abSe analizar\u00eda el colesterol LDL, el colesterol remanente y la lipoprote\u00edna(a)\u00bb, dice. \u00abHar\u00edas tres pruebas paralelas\u00bb.<\/p>\n

El cambio no consiste solo en mejorar los marcadores, sino en detectarlos antes. El riesgo cardiovascular se acumula silenciosamente durante d\u00e9cadas y, sin embargo, las pruebas no suelen empezar hasta que aparecen s\u00edntomas o factores de riesgo claros, por ejemplo, ser var\u00f3n y tener m\u00e1s de 60 a\u00f1os.<\/p>\n

\u00abSi no miras, no sabes\u00bb, resalta Ray. \u00abNormalmente, las personas de veinte, treinta y cuarenta a\u00f1os no suelen hacerse pruebas porque se sienten bien\u00bb.<\/p>\n

En su lugar, dice, la atenci\u00f3n suele ser reactiva, lo que tiene consecuencias para la prevenci\u00f3n.<\/p>\n

Adem\u00e1s de la apoB, los investigadores est\u00e1n empezando a explorar formas a\u00fan m\u00e1s granulares de medir el riesgo. El examen a gran escala de las mol\u00e9culas qu\u00edmicas producidas por el metabolismo corporal, junto con los datos gen\u00e9ticos, sugieren que el riesgo cardiovascular est\u00e1 determinado por una compleja interacci\u00f3n de v\u00edas biol\u00f3gicas, no por un \u00fanico biomarcador.<\/p>\n","protected":false},"excerpt":{"rendered":"

Investigaciones m\u00e1s recientes sugieren que el panorama...<\/p>\n","protected":false},"author":1,"featured_media":200671,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[46],"tags":[],"class_list":["post-200670","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tecnologia"],"yoast_head":"\nHay una forma mejor de medir el "colesterol malo" - Sarmiento24h<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sarmiento24h.com\/?p=200670\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hay una forma mejor de medir el "colesterol malo" - 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