{"id":215576,"date":"2026-05-17T06:27:37","date_gmt":"2026-05-17T06:27:37","guid":{"rendered":"http:\/\/6a0756be1b9a59fe3a048591"},"modified":"2026-05-17T06:27:37","modified_gmt":"2026-05-17T06:27:37","slug":"la-ciencia-tiene-un-problema-de-adn-que-esta-arruinando-miles-de-experimentos-con-ratones","status":"publish","type":"post","link":"https:\/\/sarmiento24h.com\/?p=215576","title":{"rendered":"La ciencia tiene un problema de ADN que est\u00e1 arruinando miles de experimentos con ratones"},"content":{"rendered":"

Un n\u00famero a\u00fan no determinado de ensayos cient\u00edficos basados en estudios con ratones podr\u00eda tener conclusiones sesgadas o imprecisas debido a errores en la categorizaci\u00f3n de los animales utilizados en los experimentos. As\u00ed lo sugiere una nueva investigaci\u00f3n que, tras analizar la gen\u00e9tica de cientos de cepas, descubri\u00f3 que alrededor de la mitad presentaba inconsistencias entre las caracter\u00edsticas reales de los animales y los datos reportados en sus etiquetas de identificaci\u00f3n.<\/p>\n

El uso de ratones de laboratorio en investigaciones cient\u00edficas es una pr\u00e1ctica ampliamente extendida, ya que el genoma de estos animales comparte m\u00e1s del 80% de sus componentes con el humano.<\/strong> Esta similitud no solo permite replicar distintos trastornos y enfermedades para comprender su origen y evoluci\u00f3n, sino tambi\u00e9n identificar genes<\/a> implicados en estas afecciones y, en consecuencia, desarrollar nuevos tratamientos o terapias.<\/p>\n

\n
\n
\"El<\/picture><\/span><\/div>\n
\n
Los primeros embriones de rat\u00f3n fueron cultivados con \u00e9xito en el espacio<\/a><\/div>\n

Las c\u00e9lulas lograron desarrollarse con normalidad, y los perfiles de expresi\u00f3n gen\u00e9tica fueron similares a los de un grupo de embriones cultivados de manera paralela en la Tierra.<\/p>\n<\/div>\n<\/div>\n

\n

En este contexto, como se\u00f1alan Javier Cubero y Yulia Nevzorova, profesores del departamento de Inmunolog\u00eda, Oftalmolog\u00eda y ORL de la facultad de Medicina de la Universidad Complutense de Madrid, \u201cel fondo gen\u00e9tico de un rat\u00f3n no es un detalle secundario; de hecho, es probablemente la variable experimental m\u00e1s importante y, al mismo tiempo, la menos controlada\u201d.<\/p>\n

En declaraciones retomadas por SMC Espa\u00f1a<\/em>, los especialistas explican que cuando este aspecto no se documenta con rigor no solo se compromete la respuesta de los animales frente a determinadas enfermedades o a un f\u00e1rmaco experimental, sino que tambi\u00e9n puede verse afectada la precisi\u00f3n y veracidad<\/a> de las conclusiones obtenidas en una investigaci\u00f3n.<\/p>\n

Aunque este problema era conocido en la comunidad cient\u00edfica, hasta ahora se desconoc\u00eda su verdadera magnitud. Para evaluar el alcance del fen\u00f3meno, un equipo liderado por Fernando Pardo-Manuel de Villena, genetista especializado en ratones de la Universidad de Carolina del Norte en Chapel Hill, analiz\u00f3 los genomas de 611 muestras pertenecientes a 341 cepas de ratones modificados resguardadas por los Centros de Investigaci\u00f3n y Recursos de Ratones Mutantes (MMRRC, por sus siglas en ingl\u00e9s).<\/p>\n

El grupo desarroll\u00f3 un sistema de control de calidad gen\u00e9tica que incorpor\u00f3 diversas mejoras respecto a otros m\u00e9todos similares ya existentes, entre ellas el an\u00e1lisis de m\u00faltiples muestras de cada cepa, en lugar de estudiar \u00fanicamente un ejemplar aislado, as\u00ed como estimaciones m\u00e1s robustas sobre la replicabilidad del genoma. El sistema clasifica cada cepa en una de siete categor\u00edas, con el objetivo de ofrecer a la comunidad cient\u00edfica un resumen sobre las caracter\u00edsticas reales de los animales utilizados en los experimentos.<\/p>\n

Los resultados revelaron que el 47% de las cepas analizadas no coincid\u00eda con la descripci\u00f3n declarada y que solo el 20% correspond\u00eda fielmente a las caracter\u00edsticas gen\u00e9ticas indicadas en la identificaci\u00f3n de la cepa.<\/strong><\/p>\n

De manera m\u00e1s espec\u00edfica, el an\u00e1lisis detect\u00f3 que el 7% de las muestras pertenec\u00eda a una cepa completamente distinta; el 10% presentaba modificaciones gen\u00e9ticas no registradas y el 26% correspond\u00eda a una subcepa diferente.<\/p>\n

Decenas de cruces, tiempo y dinero perdidos<\/h2>\n

Llu\u00eds Montoliu, investigador del Centro Nacional de Biotecnolog\u00eda de Espa\u00f1a, que no particip\u00f3 en el estudio, se\u00f1al\u00f3 en declaraciones retomadas por SMC Media q<\/em>ue \u201cseguramente el origen del problema deriva de la multitud de cruces de todo tipo que se han venido realizando con las miles de cepas de rat\u00f3n creadas por la comunidad cient\u00edfica\u201d.<\/p>\n

Se estima que para introducir un cambio gen\u00e9tico en una cepa es necesario realizar cruces entre ratones endog\u00e1micos durante entre 10 y 20 generaciones. Este proceso requiere registros meticulosos para evitar errores. Cuando ese control falla, parte de la variaci\u00f3n gen\u00e9tica de la cepa donante puede conservarse en la receptora, lo que provoca que las diferencias gen\u00e9ticas entre las cepas se vuelvan menos evidentes.<\/p>\n","protected":false},"excerpt":{"rendered":"

Un n\u00famero a\u00fan no determinado de ensayos...<\/p>\n","protected":false},"author":1,"featured_media":215577,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[46],"tags":[],"class_list":["post-215576","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tecnologia"],"yoast_head":"\nLa ciencia tiene un problema de ADN que est\u00e1 arruinando miles de experimentos con ratones - Sarmiento24h<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sarmiento24h.com\/?p=215576\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La ciencia tiene un problema de ADN que est\u00e1 arruinando miles de experimentos con ratones - 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