{"id":284337,"date":"2026-06-15T17:41:16","date_gmt":"2026-06-15T17:41:16","guid":{"rendered":"http:\/\/6a302b4fdb5a176ed843c76a"},"modified":"2026-06-15T17:41:16","modified_gmt":"2026-06-15T17:41:16","slug":"este-farmaco-a-base-de-cobre-busca-frenar-el-alzheimer-y-mejorar-la-memoria","status":"publish","type":"post","link":"https:\/\/sarmiento24h.com\/?p=284337","title":{"rendered":"Este f\u00e1rmaco a base de cobre busca frenar el Alzheimer y mejorar la memoria"},"content":{"rendered":"

Un f\u00e1rmaco a base de cobre, llamado Cu(Atsm), podr\u00eda convertirse en un aliado prometedor en la lucha contra la enfermedad de Alzheimer. Investigadores de la Universidad de Monash, Australia, lo sugieren en un estudio reciente publicado en ACS Chemical Neuroscience<\/em>.<\/p>\n

Descubrieron<\/a> que este compuesto a base de cobre, hasta ahora solo probado en experimentos de laboratorio, fue capaz de restaurar los mecanismos de eliminaci\u00f3n de desechos metab\u00f3licos del cerebro,<\/a> reduciendo as\u00ed las prote\u00ednas t\u00f3xicas asociadas con el Alzheimer<\/a> y mejorando la memoria.<\/p>\n

\u00bfQu\u00e9 le pasa al cerebro con el Alzheimer?<\/h2>\n

El Alzheimer se caracteriza por la acumulaci\u00f3n de beta-amiloide, una prote\u00edna que forma placas t\u00f3xicas asociadas precisamente al deterioro cognitivo. Concretamente, mientras que en condiciones normales el cerebro<\/a> consigue eliminar parte de estas sustancias al torrente sangu\u00edneo a trav\u00e9s de la barrera hematoencef\u00e1lica, en el Alzheimer<\/a>, algunos sistemas de transporte que realizan esta tarea, como por ejemplo las glicoprote\u00ednas P (P-gp), se debilitan significativamente a medida que avanza la enfermedad, volvi\u00e9ndose menos eficientes y favoreciendo la acumulaci\u00f3n de beta-amiloide en los tejidos cerebrales.<\/a><\/p>\n

\n
\"cerebro<\/picture><\/span><\/div>\n
\n
El cerebro humano como nunca lo hab\u00edamos visto<\/a><\/div>\n

Tecnolog\u00edas innovadoras y sofisticadas nos permiten seguir profundizando en el conocimiento de uno de los \u00f3rganos m\u00e1s complejos.<\/p>\n<\/div>\n<\/div>\n

Lo que encontraron los investigadores<\/h2>\n

En el nuevo estudio, se llevaron a cabo una serie de experimentos con el f\u00e1rmaco a base de cobre, demostrando que el tratamiento es capaz de restablecer parcialmente el funcionamiento de las glicoprote\u00ednas P, favoreciendo as\u00ed la eliminaci\u00f3n de la beta-amiloide acumulada. Los resultados muestran que el compuesto aument\u00f3 en un 24.1% la abundancia de prote\u00ednas P-gp en la barrera hematoencef\u00e1lica.<\/p>\n

\n
\"Collage<\/picture><\/span><\/div>\n

Fotoilustraci\u00f3n: Staff de WIRED; GETTY IMAGES<\/span><\/p>\n<\/figure>\n

\u00abEste es el primer estudio que demuestra que el Cu(Atsm) puede aumentar en un casi 25% la abundancia de las bombas P-gp en un modelo de Alzheimer<\/a>, vinculando la reparaci\u00f3n de la barrera hematoencef\u00e1lica con una reducci\u00f3n de las prote\u00ednas t\u00f3xicas y una mejora de la funci\u00f3n cognitiva\u00bb, coment\u00f3 el autor principal, Jae Pyun. A\u00f1ade que, al mejorar el funcionamiento de estos sistemas, el cerebro<\/a> puede finalmente eliminar las sustancias de desecho acumuladas.<\/p>\n

En un periodo de 56 d\u00edas, el tratamiento redujo en un 42% los niveles de beta-amiloide y mejor\u00f3 en casi un 44% el rendimiento en las pruebas de aprendizaje espacial<\/strong>, lo que sugiere que la disminuci\u00f3n de las prote\u00ednas t\u00f3xicas puede tener efectos positivos concretos sobre las funciones cognitivas.<\/a><\/p>\n

El f\u00e1rmaco a base de cobre<\/h2>\n

El f\u00e1rmaco de cobre no es un compuesto completamente nuevo, sino que ya se ha estudiado en ensayos cl\u00ednicos para otras enfermedades neurodegenerativas.<\/a><\/strong> Por lo tanto, ya se dispone de datos preliminares sobre su seguridad, lo que podr\u00eda acelerar el camino de posibles ensayos cl\u00ednicos para el Alzheimer.<\/p>\n

\u00abCu(Atsm) es un compuesto de cobre con propiedades antiinflamatorias y neuroprotectoras que ya ha alcanzado la fase de ensayos cl\u00ednicos para enfermedades como la enfermedad de Parkinson<\/a> y la esclerosis lateral amiotr\u00f3fica (ELA)\u00bb , coment\u00f3 el coautor Joseph Nicolazzo.<\/p>\n

\u00abDado que se ha demostrado que la reducci\u00f3n de la carga de amiloide mejora los resultados funcionales, estos resultados precl\u00ednicos respaldan firmemente la justificaci\u00f3n para probar este f\u00e1rmaco en las etapas sintom\u00e1ticas tempranas del Alzheimer\u00bb. Aunque los resultados son alentadores, los autores instan a la cautela: el f\u00e1rmaco de cobre hasta ahora solo se ha probado en ensayos precl\u00ednicos y, por lo tanto, a\u00fan no ha demostrado su eficacia como tratamiento en pacientes.<\/p>\n","protected":false},"excerpt":{"rendered":"

Un f\u00e1rmaco a base de cobre, llamado...<\/p>\n","protected":false},"author":1,"featured_media":284338,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[46],"tags":[],"class_list":["post-284337","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tecnologia"],"yoast_head":"\nEste f\u00e1rmaco a base de cobre busca frenar el Alzheimer y mejorar la memoria - Sarmiento24h<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sarmiento24h.com\/?p=284337\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Este f\u00e1rmaco a base de cobre busca frenar el Alzheimer y mejorar la memoria - 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