{"id":319860,"date":"2026-07-09T20:56:53","date_gmt":"2026-07-09T20:56:53","guid":{"rendered":"http:\/\/6a4ff2b957524c1ebedf644f"},"modified":"2026-07-09T20:56:53","modified_gmt":"2026-07-09T20:56:53","slug":"la-incapacidad-del-cerebro-para-eliminar-desechos-podria-estar-ligada-a-la-fatiga-cronica","status":"publish","type":"post","link":"https:\/\/sarmiento24h.com\/?p=319860","title":{"rendered":"La incapacidad del cerebro para eliminar desechos podr\u00eda estar ligada a la fatiga cr\u00f3nica"},"content":{"rendered":"

Un estudio pionero sugiere que los s\u00edntomas del s\u00edndrome de fatiga cr\u00f3nica podr\u00edan estar relacionados con un funcionamiento deficiente de los mecanismos que utiliza el cerebro para eliminar las sustancias de desecho generadas por sus c\u00e9lulas. Aunque el hallazgo es preliminar, los cient\u00edficos sostienen que podr\u00eda abrir la puerta al desarrollo de tratamientos personalizados para esta afecci\u00f3n y otras enfermedades que afectan las funciones cognitivas.<\/p>\n

El sistema glinf\u00e1tico es una red de canales que permite al cerebro eliminar toxinas y desechos metab\u00f3licos<\/a> acumulados durante el d\u00eda. La existencia de este mecanismo se document\u00f3 por primera vez en ratones hace cerca de 14 a\u00f1os y, el a\u00f1o pasado, fue identificada<\/a> por primera vez en seres humanos.<\/strong><\/p>\n

Aunque el conocimiento sobre su funcionamiento todav\u00eda es limitado, se sabe que una alteraci\u00f3n en esta red puede provocar inflamaci\u00f3n en el sistema nervioso central, disminuir la capacidad de procesamiento del cerebro y favorecer la aparici\u00f3n de diversos s\u00edntomas neurol\u00f3gicos.<\/p>\n

\n
\n
\"fatiga<\/picture><\/span><\/div>\n
\n
La fatiga cr\u00f3nica podr\u00eda ser biol\u00f3gica y no s\u00f3lo psicol\u00f3gica<\/a><\/div>\n

Cansancio extremo, problemas para dormir y poca concentraci\u00f3n son algunos s\u00edntomas de fatiga cr\u00f3nica. Cualquier persona puede padecerla, pero es m\u00e1s com\u00fan en mujeres y suele desarrollarse entre los 20 y 40 a\u00f1os.<\/p>\n<\/div>\n<\/div>\n

\n

En los \u00faltimos a\u00f1os, distintos grupos de investigaci\u00f3n han comenzado a estudiar la posible relaci\u00f3n entre este fen\u00f3meno y problemas como el deterioro cognitivo, los d\u00e9ficits de memoria, las alteraciones musculoesquel\u00e9ticas y la psicosis.<\/strong> Sin embargo, hasta ahora no se hab\u00eda evaluado su posible v\u00ednculo con el s\u00edndrome de fatiga cr\u00f3nica o encefalomielitis mi\u00e1lgica (EM\/SFC).<\/p>\n

Con el objetivo de investigar esta posibilidad, un equipo de la Universidad de Griffith (en Australia) analiz\u00f3 el funcionamiento del sistema glinf\u00e1tico en 31 pacientes diagnosticados con EM\/SFC y en 27 personas sanas.<\/p>\n

En una primera etapa, todos los participantes que presentaban caracter\u00edsticas demogr\u00e1ficas y edades similares respondieron una serie de cuestionarios estandarizados dise\u00f1ados para determinar la presencia, intensidad y frecuencia de los s\u00edntomas asociados<\/a> con el s\u00edndrome de fatiga cr\u00f3nica.<\/p>\n

An\u00e1lisis del sistema de limpieza del cerebro<\/h2>\n

Posteriormente, los investigadores evaluaron el funcionamiento del sistema glinf\u00e1tico con una resonancia magn\u00e9tica cerebral basada en una t\u00e9cnica conocida como Diffusion Tensor Imaging Analysis Along the Perivascular Space<\/em> (DTI-ALPS).<\/p>\n

A diferencia de otros procedimientos que requieren la administraci\u00f3n de sustancias de contraste mediante una inyecci\u00f3n, el m\u00e9todo DTI-ALPS utiliza un equipo de resonancia magn\u00e9tica de 3 teslas para obtener im\u00e1genes cerebrales de alta resoluci\u00f3n. Aunque esta t\u00e9cnica suele ser menos directa y precisa que los m\u00e9todos tradicionales, permiti\u00f3 detectar la direcci\u00f3n y la intensidad de los fluidos que circulan por los espacios perivasculares utilizados por el sistema glinf\u00e1tico.<\/strong> Con esa informaci\u00f3n, los investigadores estimaron la eficiencia del proceso de limpieza cerebral por un indicador denominado \u00edndice DTI-ALPS.<\/p>\n

Los cient\u00edficos calcularon \u00edndices DTI-ALPS espec\u00edficos para cada hemisferio cerebral, adem\u00e1s de un promedio global para todo el cerebro. Con base en esos valores analizaron las im\u00e1genes obtenidas tanto de los pacientes con EM\/SFC como de las personas sanas, y compararon los resultados mediante modelos estad\u00edsticos ajustados por variables como la edad y el sexo.<\/p>\n

El estudio, publicado<\/a> en la revista Frontiers in Neuroscience<\/em>, explica que un \u00edndice DTI-ALPS elevado permite inferir un funcionamiento m\u00e1s eficiente del sistema glinf\u00e1tico. En cambio, valores bajos sugieren que el proceso de eliminaci\u00f3n de desechos cerebrales es menos eficiente.<\/p>\n

\n
\"fatiga<\/picture><\/span><\/div>\n
<\/p>\n

Imagen de las regiones de inter\u00e9s para los c\u00e1lculos del \u00edndice DTI-ALPS.<\/p>\n

<\/span>Cortes\u00eda Frontiers in Neuroscience<\/span><\/div>\n<\/figure>\n

\u00bfC\u00f3mo se relacionan los desechos cerebrales con los s\u00edntomas de fatiga cr\u00f3nica?<\/h2>\n

Los resultados mostraron que los participantes con s\u00edndrome de fatiga cr\u00f3nica presentaban un \u00edndice DTI-ALPS global significativamente menor que el observado en las personas sanas. Este hallazgo indica que, en promedio, el sistema glinf\u00e1tico del primer grupo funcionaba con menor eficiencia.<\/p>\n

Al analizar cada hemisferio por separado, los investigadores descubrieron que, entre las personas con EM\/SFC, el hemisferio derecho presentaba una funci\u00f3n glinf\u00e1tica inferior a la del izquierdo<\/strong>. Esta diferencia no se observ\u00f3 en los participantes sanos.<\/p>\n","protected":false},"excerpt":{"rendered":"

Un estudio pionero sugiere que los s\u00edntomas...<\/p>\n","protected":false},"author":1,"featured_media":319861,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[46],"tags":[],"class_list":["post-319860","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tecnologia"],"yoast_head":"\nLa incapacidad del cerebro para eliminar desechos podr\u00eda estar ligada a la fatiga cr\u00f3nica - 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