{"id":383681,"date":"2026-08-17T22:29:57","date_gmt":"2026-08-17T22:29:57","guid":{"rendered":"http:\/\/6a834ef97baee8f73492b96d"},"modified":"2026-08-17T22:29:57","modified_gmt":"2026-08-17T22:29:57","slug":"el-inesperado-vinculo-entre-la-contaminacion-del-aire-el-grosor-del-cerebro-y-el-riesgo-de-alzheimer","status":"publish","type":"post","link":"https:\/\/sarmiento24h.com\/?p=383681","title":{"rendered":"El inesperado v\u00ednculo entre la contaminaci\u00f3n del aire, el grosor del cerebro y el riesgo de Alzheimer"},"content":{"rendered":"

La exposici\u00f3n a contaminantes comunes del aire est\u00e1 asociada con diferencias en el grosor de la corteza cerebral, seg\u00fan un estudio publicado en NeuroToxicology<\/em>. Investigadores de la Universidad del Sur de California (USC) analizaron im\u00e1genes cerebrales y estimaciones de exposici\u00f3n a part\u00edculas finas PM2.5 y di\u00f3xido de nitr\u00f3geno (NO2) de adultos sin demencia. Seg\u00fan los resultados, entre las personas de edad avanzada, una mayor exposici\u00f3n se relacion\u00f3 con una corteza m\u00e1s delgada. Entre los participantes m\u00e1s j\u00f3venes, en cambio, los investigadores observaron una asociaci\u00f3n con mayor grosor.<\/p>\n

Los neur\u00f3logos ponen atenci\u00f3n al adelgazamiento cortical porque puede reflejar p\u00e9rdida o deterioro del tejido cerebral. Esta parte del cerebro adelgaza de manera natural con la edad, pero las enfermedades neurodegenerativas pueden acelerar ese proceso. En este estudio, los investigadores pusieron especial atenci\u00f3n en cuatro regiones particularmente vulnerables a la enfermedad de Alzheimer<\/a>: las cortezas entorrinal, fusiforme, temporal inferior y temporal media. En conjunto, estas zonas mostraron diferencias de grosor asociadas con la contaminaci\u00f3n del aire.<\/p>\n

\n
\n
\"Simulaci\u00f3n<\/picture><\/span><\/div>\n
\n
As\u00ed es la copia virtual del cerebro m\u00e1s detallada que ayudar\u00e1 a estudiar enfermedades neurodegenerativas<\/a><\/div>\n

Neurocient\u00edficos simulan millones de neuronas para explorar c\u00f3mo se propaga el Alzheimer antes de que aparezcan los primeros s\u00edntomas.<\/p>\n<\/div>\n<\/div>\n

\n

La extra\u00f1a relaci\u00f3n entre contaminaci\u00f3n y cambios en el cerebro<\/h2>\n

Los investigadores analizaron informaci\u00f3n de dos grandes estudios estadounidenses sobre envejecimiento. El primero, el Vietnam Era Twin Study of Aging (VETSA), aport\u00f3 datos de 387 hombres de alrededor de 62 a\u00f1os. El segundo, el Women\u2019s Health Initiative Memory Study (WHIMS), incluy\u00f3 a 1,097 mujeres de aproximadamente 78 a\u00f1os. Ninguno de los participantes incluidos en el an\u00e1lisis ten\u00eda demencia ni hab\u00eda sufrido un accidente cerebrovascular antes de la resonancia magn\u00e9tica. Los cient\u00edficos utilizaron esas im\u00e1genes para medir el grosor de 34 regiones de la corteza cerebral.<\/a><\/p>\n

Las part\u00edculas PM2.5, que suelen generarse durante la combusti\u00f3n de combustibles f\u00f3siles o en incendios, mostraron la asociaci\u00f3n m\u00e1s extendida con diferencias en el grosor. En las mujeres mayores, los investigadores relacionaron este contaminante con un menor grosor en 23 de las 34 regiones corticales analizadas, distribuidas por los cuatro l\u00f3bulos del cerebro. En t\u00e9rminos de grosor cortical, el efecto asociado con las PM2.5 fue comparable a alrededor de un a\u00f1o adicional de envejecimiento.<\/p>\n

En los hombres m\u00e1s j\u00f3venes ocurri\u00f3 lo contrario. Los investigadores asociaron una mayor exposici\u00f3n a PM2.5 y NO2<\/a> con una corteza m\u00e1s gruesa en el conjunto de regiones vulnerables al Alzheimer. En el caso de las PM2.5, adem\u00e1s, esta relaci\u00f3n cambi\u00f3 conforme aumentaba la edad: el engrosamiento asociado con la contaminaci\u00f3n disminuy\u00f3 entre los 55 y los 64 a\u00f1os y, despu\u00e9s de los 64, la tendencia se invirti\u00f3 (aunque la asociaci\u00f3n negativa posterior no fue estad\u00edsticamente significativa).<\/p>\n

C\u00f3mo interpretar una contradicci\u00f3n<\/h2>\n

Los resultados<\/a> plantean una aparente contradicci\u00f3n para la cual los investigadores consideran al menos dos explicaciones: que exista una trayectoria no lineal, en la que la contaminaci\u00f3n se relacione primero con un mayor grosor y posteriormente con adelgazamiento cortical, o que el cerebro responda de manera diferente a estos contaminantes dependiendo de la edad. El estudio no permite distinguir entre ambas posibilidades.<\/p>\n

\u201cNuestros hallazgos plantean la posibilidad de que los cambios cerebrales relacionados con la contaminaci\u00f3n no sean lineales\u201d, explic\u00f3 Lauren Salminen, autora principal del estudio. en un comunicado<\/a>. La investigadora subray\u00f3 que se trata de una hip\u00f3tesis que deber\u00e1 comprobarse siguiendo a las mismas personas conforme envejecen e incorporando biomarcadores de Alzheimer.<\/p>\n

Si bien el estudio no permite afirmar que una mayor exposici\u00f3n a contaminantes aumente el riesgo de Alzheimer, tampoco aparece en un vac\u00edo cient\u00edfico sobre el tema. Sus resultados se suman a una creciente evidencia de que las PM2.5 se relacionan con efectos sobre la salud cerebral. Una revisi\u00f3n sistem\u00e1tica publicada en The BMJ<\/em><\/a>, que reuni\u00f3 51 estudios, encontr\u00f3 evidencia de una asociaci\u00f3n entre la exposici\u00f3n a estas part\u00edculas y un mayor riesgo de demencia.<\/p>\n","protected":false},"excerpt":{"rendered":"

La exposici\u00f3n a contaminantes comunes del aire...<\/p>\n","protected":false},"author":1,"featured_media":383682,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[46],"tags":[],"class_list":["post-383681","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tecnologia"],"yoast_head":"\nEl inesperado v\u00ednculo entre la contaminaci\u00f3n del aire, el grosor del cerebro y el riesgo de Alzheimer - 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