{"id":420343,"date":"2026-09-08T22:07:23","date_gmt":"2026-09-08T22:07:23","guid":{"rendered":"http:\/\/6aa058e7f6799f480605e0f4"},"modified":"2026-09-08T22:07:23","modified_gmt":"2026-09-08T22:07:23","slug":"un-farmaco-para-la-artritis-sorprende-por-su-eficacia-contra-la-calvicie-autoinmune","status":"publish","type":"post","link":"https:\/\/sarmiento24h.com\/?p=420343","title":{"rendered":"Un f\u00e1rmaco para la artritis sorprende por su eficacia contra la calvicie autoinmune"},"content":{"rendered":"

Aproximadamente dos de cada 100 personas desarrollan alopecia areata en alg\u00fan momento de la vida, una enfermedad autoinmune y cr\u00f3nica caracterizada por la p\u00e9rdida de cabello o vello, usualmente en parches. Como el problema se origina en una respuesta an\u00f3mala del sistema inmunitario contra los fol\u00edculos pilosos, tratar este tipo de calvicie supone dificultades.<\/p>\n

Sin embargo, una posible respuesta est\u00e1 llegando desde otro frente: upadacitinib, un medicamento utilizado para tratar enfermedades inflamatorias como la artritis reumatoide, logr\u00f3 una recuperaci\u00f3n importante del cabello en dos grandes ensayos cl\u00ednicos.<\/p>\n

Aunque la artritis reumatoide y la alopecia areata parecen problemas muy distintos, ambas tienen algo en com\u00fan: el sistema inmunitario funciona de manera anormal y provoca inflamaci\u00f3n. Upadacitinib bloquea una de las rutas que usan las c\u00e9lulas inmunitarias para enviar esas se\u00f1ales. Si funciona en una enfermedad, podr\u00eda tener buenos resultados en la otra.<\/p>\n

\n
\n
\"Una<\/picture><\/span><\/div>\n
\n
C\u00f3mo prevenir la ca\u00edda del pelo antes de que sea demasiado tarde<\/a><\/div>\n

El internet est\u00e1 lleno de promesas enga\u00f1osas contra la ca\u00edda del pelo. Aqu\u00ed te contamos qu\u00e9 tratamientos realmente podr\u00edan ayudarte (y cu\u00e1les no) frente a la calvicie que ha afectado a generaciones en muchas familias.<\/p>\n<\/div>\n<\/div>\n

\n

Ya hab\u00eda indicios cl\u00ednicos de que upadacitinib pod\u00eda beneficiar a pacientes con alopecia<\/a> areata. Sin embargo, la evidencia disponible proven\u00eda principalmente de reportes de casos y experiencias limitadas, no de ensayos amplios dise\u00f1ados para medir de forma rigurosa sus beneficios y riesgos.<\/p>\n

Adi\u00f3s a este tipo de calvicie<\/h2>\n

Los nuevos resultados provienen de dos ensayos cl\u00ednicos fase 3 en los que participaron 1,399 personas de entre 12 y 64 a\u00f1os con alopecia areata grave. Para entrar al estudio, los participantes deb\u00edan haber perdido al menos la mitad del cabello del cuero cabelludo. Fueron divididos al azar en tres grupos: uno recibi\u00f3 15 miligramos de upadacitinib al d\u00eda, otro 30 miligramos y un tercero placebo.<\/p>\n

Despu\u00e9s de 24 semanas, alrededor de 45% de quienes recibieron 15 miligramos y entre 54 y 55% de quienes recibieron 30 miligramos experimentaron un crecimiento de al menos el 80% del cabello de su cuero cabelludo.<\/strong> Pr\u00e1cticamente la mitad de los participantes que recibieron el tratamiento. En los grupos placebo, apenas entre 1.5 y 3.4% alcanz\u00f3 ese resultado.<\/p>\n

Pero eso no es todo. De acuerdo con el estudio publicado en JAMA Dermatology<\/em><\/a>, entre 13 y 14% de los pacientes tratados con 15 miligramos y entre 20% y 22.5% de quienes recibieron 30 miligramos lograron una recuperaci\u00f3n completa del cabello del cuero cabelludo a las 24 semanas<\/strong>. Adem\u00e1s, hubo mejoras en el crecimiento de cejas y pesta\u00f1as y en varias medidas relacionadas con la calidad de vida.<\/p>\n

Los efectos secundarios fueron frecuentes, aunque en su mayor\u00eda no fueron graves. Entre los m\u00e1s comunes estuvieron el acn\u00e9<\/a>, las infecciones respiratorias, la nasofaringitis y el aumento de una enzima muscular en sangre. Los eventos adversos graves fueron poco frecuentes: ocurrieron en 1.6% de quienes recibieron 15 miligramos, 2.3% con 30 miligramos y 0.4% con placebo.<\/p>\n

Los resultados de fase 3 representan uno de los \u00faltimos pasos cl\u00ednicos antes de una posible aprobaci\u00f3n regulatoria del f\u00e1rmaco para tratar la alopecia areata.<\/p>\n

El estudio fue financiado por AbbVie, fabricante de upadacitinib. La compa\u00f1\u00eda tambi\u00e9n particip\u00f3 en el dise\u00f1o, recopilaci\u00f3n, an\u00e1lisis e interpretaci\u00f3n de los datos y en la preparaci\u00f3n del manuscrito. Varios autores declararon v\u00ednculos financieros con AbbVie y otras farmac\u00e9uticas. Estos conflictos no invalidan los resultados, pero s\u00ed son relevantes al interpretar sus conclusiones.<\/p>\n","protected":false},"excerpt":{"rendered":"

Aproximadamente dos de cada 100 personas desarrollan...<\/p>\n","protected":false},"author":1,"featured_media":420344,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[46],"tags":[],"class_list":["post-420343","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tecnologia"],"yoast_head":"\nUn f\u00e1rmaco para la artritis sorprende por su eficacia contra la calvicie autoinmune - 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