{"id":459987,"date":"2026-09-30T22:49:40","date_gmt":"2026-09-30T22:49:40","guid":{"rendered":"http:\/\/6abc286e82e93f8c9ce0f6de"},"modified":"2026-09-30T22:49:40","modified_gmt":"2026-09-30T22:49:40","slug":"el-adn-de-bebes-concebidos-in-vitro-tiene-una-peculiar-firma-genetica","status":"publish","type":"post","link":"https:\/\/sarmiento24h.com\/?p=459987","title":{"rendered":"El ADN de beb\u00e9s concebidos in vitro tiene una peculiar firma gen\u00e9tica"},"content":{"rendered":"

Se estima que los tratamientos de reproducci\u00f3n asistida, como la fertilizaci\u00f3n in vitro<\/em><\/strong> (FIV), han permitido el nacimiento de alrededor de 13 millones de ni\u00f1os en todo el mundo. Sin embargo, algunas investigaciones han planteado una asociaci\u00f3n entre estos procedimientos y una incidencia ligeramente mayor de ciertas enfermedades en personas concebidas por medio de estas t\u00e9cnicas.<\/p>\n

Ahora, una nueva investigaci\u00f3n identific\u00f3 una peculiar firma gen\u00e9tica<\/strong> en beb\u00e9s concebidos mediante FIV asociada con fragmentos de ADN conocidos de manera coloquial como \u201cgenes saltarines\u201d. El hallazgo puede contribuir al debate sobre la seguridad de las t\u00e9cnicas de reproducci\u00f3n asistida<\/a>.<\/p>\n

Hasta el momento, no existe evidencia concluyente que permita relacionar directamente los posibles efectos de los tratamientos de reproducci\u00f3n asistida con la salud futura<\/strong> de los individuos concebidos por estas v\u00edas. Como en cualquier gestaci\u00f3n, en el bienestar de los reci\u00e9n nacidos intervienen factores como la salud de los padres, las caracter\u00edsticas del embarazo y las condiciones que rodean el desarrollo.<\/a><\/p>\n

\n
\n
\"Detalle<\/picture><\/span><\/div>\n
\n
\u00bfQu\u00e9 ocurre cuando los embriones congelados no se utilizan?<\/a><\/div>\n

Se trata de blastocistos, o c\u00e9lulas en desarrollo, que se crioconservan y, seg\u00fan la ley de algunos pa\u00edses, pueden abandonarse.<\/p>\n<\/div>\n<\/div>\n

\n

Sin embargo, cient\u00edficos de la Universidad Sun Yat-sen, en China, descubrieron que los ni\u00f1os concebidos por FIV presentan una expresi\u00f3n molecular diferente de la observada en aquellos concebidos de manera natural, relacionada con los LINE-1<\/strong> (elemento nucleot\u00eddico intercalado largo-1), un tipo de elemento gen\u00e9tico que podr\u00eda ayudar a comprender mejor los efectos de estas t\u00e9cnicas.<\/p>\n

Los LINE-1 son fragmentos de ADN capaces de copiarse a s\u00ed mismos y colocar esas r\u00e9plicas en otras partes del genoma. Cuando esto sucede, pueden modificar la estructura o el funcionamiento de determinadas regiones gen\u00e9ticas. Este proceso puede ser m\u00e1s frecuente bajo condiciones de estr\u00e9s celular.<\/p>\n

Con base en este conocimiento, los investigadores se plantearon la siguiente interrogante: \u00bflos procedimientos de FIV pueden actuar como un tipo de estr\u00e9s durante las primeras etapas del desarrollo y modificar la cantidad o distribuci\u00f3n de estos elementos en el genoma?<\/strong><\/p>\n

M\u00e1s \u201cgenes saltarines\u201d no significa mayor riesgo de enfermedades<\/h2>\n

Para abordar esta inc\u00f3gnita, los cient\u00edficos secuenciaron el genoma completo de 75 ni\u00f1os: 33 hab\u00edan sido concebidos por FIV y 42 sin tratamiento de fertilidad. Para ello, utilizaron muestras de sangre del cord\u00f3n umbilical obtenidas al momento del nacimiento.<\/p>\n

Mediante el uso de una herramienta bioinform\u00e1tica conocida como Bowtie2, los especialistas determinaron la cantidad de ADN correspondiente a los LINE-1 en cada genoma y compararon los resultados entre ambos grupos.<\/p>\n

Despu\u00e9s, utilizaron el programa inform\u00e1tico Mobile Element Locator Tool para identificar diferencias en el material gen\u00e9tico y determinar en qu\u00e9 partes espec\u00edficas del genoma se concentraban los LINE-1. Tambi\u00e9n buscaron cambios que pudieran haber surgido durante el desarrollo y que no necesariamente estuvieran presentes en los padres.<\/p>\n

Finalmente, analizaron los genes cercanos a las posiciones donde los LINE-1 mostraban diferencias y utilizaron la base de datos DAVID (Database for Annotation, Visualization and Integrated Discovery) para estudiar asociaciones con enfermedades y funciones biol\u00f3gicas.<\/p>\n

Los hallazgos, publicados<\/a> en la revista American Journal of Obstetrics & Gynecology<\/em>, mostraron que los ni\u00f1os concebidos mediante FIV ten\u00edan una cantidad ligeramente mayor de ADN LINE-1 en todo el genoma en comparaci\u00f3n con aquellos concebidos de manera natural.<\/strong><\/p>\n

Los resultados tambi\u00e9n fueron examinados mediante el an\u00e1lisis de tres pares de hermanos, uno de ellos concebido por reproducci\u00f3n asistida. En las tres familias estudiadas, los investigadores encontraron que el ni\u00f1o concebido por FIV presentaba una mayor cantidad de LINE-1 que su hermano o hermana concebido de manera natural. La coincidencia es relevante porque los hermanos comparten buena parte de su informaci\u00f3n gen\u00e9tica<\/a> y ten\u00edan los mismos padres.<\/p>\n

Respecto a las zonas donde se ubicaban los LINE-1, los investigadores encontraron una mayor presencia de estos \u201cgenes saltarines\u201d en regiones del ADN que contienen genes previamente relacionados con enfermedades metab\u00f3licas, cardiovasculares, neuropsiqui\u00e1tricas y neopl\u00e1sicas.<\/p>\n","protected":false},"excerpt":{"rendered":"

Se estima que los tratamientos de reproducci\u00f3n...<\/p>\n","protected":false},"author":1,"featured_media":459988,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[46],"tags":[],"class_list":["post-459987","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tecnologia"],"yoast_head":"\nEl ADN de beb\u00e9s concebidos in vitro tiene una peculiar firma gen\u00e9tica - 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