{"id":461471,"date":"2026-10-01T18:06:57","date_gmt":"2026-10-01T18:06:57","guid":{"rendered":"http:\/\/6abe89db03b0a13d8afacdfb"},"modified":"2026-10-01T18:06:57","modified_gmt":"2026-10-01T18:06:57","slug":"claude-encontro-un-posible-pariente-de-crispr-en-menos-de-24-horas","status":"publish","type":"post","link":"https:\/\/sarmiento24h.com\/?p=461471","title":{"rendered":"Claude encontr\u00f3 un posible pariente de CRISPR en menos de 24 horas"},"content":{"rendered":"<p>En un comunicado del 23 de septiembre, Anthropic afirm\u00f3 que su gran modelo de lenguaje (LLM), Claude, hab\u00eda identificado un sistema enzim\u00e1tico con propiedades \u00abque recuerdan a CRISPR\u00bb, la herramienta de edici\u00f3n gen\u00e9rica galardonada con el Premio Nobel.<\/p>\n<p>Seg\u00fan Anthropic, unos 950 <a href=\"https:\/\/es.wired.com\/articulos\/ponemos-a-prueba-claude-cowork-por-fin-un-agente-de-ia-sabe-usar-tu-computadora\">agentes de Claude<\/a> que funcionaban simult\u00e1neamente encontraron las secuencias gen\u00e9ticas de inter\u00e9s en 21.5 horas. \u00abFelicito sinceramente a Anthropic por dar a conocer al mundo su descubrimiento\u00bb, afirma Fyodor Urnov, experto en <a href=\"https:\/\/es.wired.com\/articulos\/olvida-los-transgenicos-el-futuro-de-la-alimentacion-esta-en-la-edicion-genetica-crispr\">edici\u00f3n gen\u00e9tica<\/a> de la Universidad de California en Berkeley y director de I+D (Investigaci\u00f3n y Desarrollo) terap\u00e9utica en su Instituto de Gen\u00f3mica Innovadora (IGI). El IGI colabora con Anthropic, pero no ha participado en el nuevo descubrimiento.<\/p>\n<p>Otros cient\u00edficos se muestran menos entusiastas con el hallazgo, que es el primero que surge de un grupo de investigaci\u00f3n formado por Anthropic a principios de este a\u00f1o. \u00abLos experimentos a\u00fan est\u00e1n en curso. El comunicado de prensa ya est\u00e1 publicado\u00bb, afirma Le Cong, profesor de la Universidad de Stanford especializado en la integraci\u00f3n de la IA en la investigaci\u00f3n sobre ingenier\u00eda gen\u00f3mica.<\/p>\n<p>Anthropic, que ha creado un laboratorio de investigaci\u00f3n para el <a href=\"https:\/\/es.wired.com\/articulos\/donde-estan-todos-los-medicamentos-que-la-ia-nos-prometio\">descubrimiento de f\u00e1rmacos<\/a>, ha dejado claro que este hallazgo no supone el final de su trabajo. \u00abA\u00fan no entendemos qu\u00e9 hace este sistema, pero solo un pu\u00f1ado de sistemas conocidos comparten sus caracter\u00edsticas, y todos ellos son capaces de cortar, copiar y pegar ADN\u00bb, afirm\u00f3 la empresa en una publicaci\u00f3n en X. Se incluy\u00f3 un experimento f\u00edsico en un informe t\u00e9cnico, que a\u00fan no ha sido revisado por pares. Sin embargo, queda mucho por hacer para determinar la importancia de este descubrimiento. Sigue sin saberse si este sistema enzim\u00e1tico puede utilizarse como <a href=\"https:\/\/es.wired.com\/articulos\/crispr-guia-completa-wired-sobre-herramienta-de-edicion-genetica\">herramienta de edici\u00f3n gen\u00e9tica<\/a> y, en caso afirmativo, si resulta \u00fatil para tal fin.<\/p>\n<p>\u00abImaginemos que estamos en la playa de Santa M\u00f3nica e intentamos examinar toda la arena para encontrar un diamante. La IA ha encontrado algo que brilla mucho, y entonces hay que volver al laboratorio para saber: \u00bfes cristal? \u00bfEs un diamante?\u00bb, explica Cong.<\/p>\n<p>Claude encontr\u00f3 este hallazgo despu\u00e9s de que investigadores de Anthropic le pidieran buscar en enormes bases de datos gen\u00f3micas \u00abnuevos ejemplos interesantes\u00bb de transcriptasas inversas, prote\u00ednas capaces de copiar ARN en ADN. Este proceso ocurre en sentido contrario al habitual en nuestras c\u00e9lulas, donde el ADN se transcribe en ARN. Sin embargo, otros organismos utilizan las transcriptasas inversas para distintas funciones biol\u00f3gicas, entre ellas la inserci\u00f3n de <a href=\"https:\/\/es.wired.com\/articulos\/partes-del-adn-humano-evolucionan-mas-rapido-de-lo-que-se-pensaba-incluso-de-una-generacion-a-otra-descubre-estudio\">segmentos de ADN.<\/a><\/p>\n<div class=\"ContentCardEmbedWrapper-hkvhYu kMYDit content-card-embed content-card-embed--stacked\" data-testid=\"ContentCardEmbedWrapper\" readability=\"18.980769230769\">\n<div class=\"ContentCardEmbedImage-bqahne fjmzkP content-card-embed__image\" data-testid=\"ContentCardEmbedImage\"><span class=\"SpanWrapper-kFnjvc eKnjjD responsive-asset\"><picture class=\"ResponsiveImagePicture-jKunQM gjCCFj responsive-image\"><img decoding=\"async\" alt=\"Una startup de Carolina del Norte llamada Pairwise est\u00e1 utilizando la tecnolog\u00eda de edici\u00f3n gen\u00e9tica conocida como CRISPR \" loading=\"lazy\" class=\"ResponsiveImageContainer-dkeESL cQPiWi responsive-image__image\" srcset=\"https:\/\/media.es.wired.com\/photos\/6a7ba54c268bba267e6eeef0\/master\/w_120,c_limit\/Tom%20Adams%20in%20Greenhouse%20with%20Blackberry.jpg 120w, https:\/\/media.es.wired.com\/photos\/6a7ba54c268bba267e6eeef0\/master\/w_240,c_limit\/Tom%20Adams%20in%20Greenhouse%20with%20Blackberry.jpg 240w, https:\/\/media.es.wired.com\/photos\/6a7ba54c268bba267e6eeef0\/master\/w_320,c_limit\/Tom%20Adams%20in%20Greenhouse%20with%20Blackberry.jpg 320w, https:\/\/media.es.wired.com\/photos\/6a7ba54c268bba267e6eeef0\/master\/w_640,c_limit\/Tom%20Adams%20in%20Greenhouse%20with%20Blackberry.jpg 640w, https:\/\/media.es.wired.com\/photos\/6a7ba54c268bba267e6eeef0\/master\/w_768,c_limit\/Tom%20Adams%20in%20Greenhouse%20with%20Blackberry.jpg 768w\" sizes=\"100vw\" src=\"https:\/\/media.es.wired.com\/photos\/6a7ba54c268bba267e6eeef0\/master\/w_775%2Cc_limit\/Tom%2520Adams%2520in%2520Greenhouse%2520with%2520Blackberry.jpg\"><\/picture><\/span><\/div>\n<div class=\"ContentCardEmbedInfo-buyHWH gWLOee\" readability=\"19.884615384615\">\n<div class=\"BaseText-fEwdHD ContentCardEmbedHed-kDKGDs iUENtL dlHXUJ content-card-embed__hed\" data-testid=\"ContentCardEmbedHed\"><a class=\"BaseLink-haTOKm ContentCardEmbedHedLink-iBZsco ILkR hhUFQU content-card-embed__hed-link link\" href=\"https:\/\/es.wired.com\/articulos\/olvida-los-transgenicos-el-futuro-de-la-alimentacion-esta-en-la-edicion-genetica-crispr\" data-testid=\"ContentCardEmbedHedLink\">Olvida los transg\u00e9nicos: el futuro de la alimentaci\u00f3n est\u00e1 en la edici\u00f3n gen\u00e9tica CRISPR<\/a><\/div>\n<p>Startups and Big Ag are using Crispr gene editing to create crops that taste better and grow on a hotter planet. But will they find a market?<\/p>\n<\/div>\n<\/div>\n<h2>Anthropic llama a su sistema ART<\/h2>\n<p>Seg\u00fan Anthropic, los agentes de Claude identificaron inicialmente m\u00e1s de 200,000 posibles transcriptasas inversas. Despu\u00e9s redujeron la lista a varios miles de candidatos que parec\u00edan ser nuevos y siguieron filtr\u00e1ndolos hasta encontrar una familia \u00abinusual\u00bb de estas prote\u00ednas, asociada a una larga regi\u00f3n de secuencias de ADN repetidas similares a CRISPR.<\/p>\n<p>Anthropic llama a este sistema ART, siglas de <em>array-associated reverse transcriptases<\/em> (transcriptasas inversas asociadas a matrices). El sistema aparece en fagos gigantes, virus de gran tama\u00f1o que infectan bacterias.<\/p>\n<p>\u00abPuedo ver a simple vista una matriz de repeticiones en t\u00e1ndem\u2026 \u00bfes eso una matriz de repeticiones similar a CRISPR?\u00bb, escribi\u00f3 un <a href=\"https:\/\/es.wired.com\/articulos\/instinct-es-el-primer-agente-de-ia-al-que-realmente-estoy-dispuesta-delegar-mis-datos\">agente de IA.<\/a> El agente tambi\u00e9n identific\u00f3 que este sistema podr\u00eda ser un retr\u00f3n, como se\u00f1ala el informe t\u00e9cnico. Tanto CRISPR como los retrones forman parte de los sistemas de defensa de las bacterias, aunque funcionan de manera distinta. Los retrones tambi\u00e9n pueden aprovecharse para la edici\u00f3n gen\u00e9tica, pero no son una herramienta tan vers\u00e1til como CRISPR. Por eso, no sorprende que Anthropic destacara sobre todo la comparaci\u00f3n con CRISPR en su publicaci\u00f3n.<\/p>\n<p>Seth Shipman, investigador asociado de los Institutos Gladstone, no cree que lo que ha encontrado Anthropic sea un nuevo sistema CRISPR, pero afirma que el descubrimiento sigue siendo interesante. \u00abLo novedoso es c\u00f3mo lo encontraron, no lo que es\u00bb, afirma. Su laboratorio ha utilizado retrones para crear sistemas de <a href=\"https:\/\/es.wired.com\/articulos\/logran-editar-con-precision-el-adn-de-embriones-humanos-acercando-la-posibilidad-de-bebes-modificados-geneticamente\">edici\u00f3n gen\u00e9tica<\/a>, por lo que es posible emplear los retrones de esta manera.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>En un comunicado del 23 de septiembre,&#46;&#46;&#46;<\/p>\n","protected":false},"author":1,"featured_media":461472,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[46],"tags":[],"class_list":["post-461471","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tecnologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - 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