{"id":479324,"date":"2026-10-11T19:06:46","date_gmt":"2026-10-11T19:06:46","guid":{"rendered":"http:\/\/6ac937f86d9826e80bf477f8"},"modified":"2026-10-11T19:06:46","modified_gmt":"2026-10-11T19:06:46","slug":"logran-rejuvenecer-celulas-humanas-reprogramandolas-las-que-parecian-de-80-anos-ahora-lucen-de-20","status":"publish","type":"post","link":"https:\/\/sarmiento24h.com\/?p=479324","title":{"rendered":"Logran rejuvenecer c\u00e9lulas humanas reprogram\u00e1ndolas: las que parec\u00edan de 80 a\u00f1os ahora lucen de 20"},"content":{"rendered":"<p>Cient\u00edficos en Alemania lograron que c\u00e9lulas tomadas de personas de unos 80 a\u00f1os parecieran tener cerca de 20 despu\u00e9s de someterlas a un proceso de reprogramaci\u00f3n. El efecto fue tan marcado que uno de los relojes usados para medir el envejecimiento celular retrocedi\u00f3 varias d\u00e9cadas.<\/p>\n<p>Los investigadores partieron de c\u00e9lulas de la sangre de personas de distintas edades, incluido un donante de 101 a\u00f1os, y las llevaron a convertirse en c\u00e9lulas capaces de dar origen a c\u00e9lulas del sistema nervioso. Conforme avanz\u00f3 esa transformaci\u00f3n, cambiaron tambi\u00e9n las se\u00f1ales qu\u00edmicas en el ADN que ayudan a estimar la <a href=\"https:\/\/es.wired.com\/articulos\/hallan-el-reloj-oculto-de-los-espermatozoides-que-muestra-su-envejecimiento\">edad de una c\u00e9lula<\/a>.<\/p>\n<p>La transformaci\u00f3n de precursores de gl\u00f3bulos rojos a c\u00e9lulas madre neurales fue paulatina. El cambio en la edad tambi\u00e9n. Al cabo de varias semanas, las c\u00e9lulas reprogramadas hab\u00edan borrado buena parte de las se\u00f1ales que distingu\u00edan a las viejas de las j\u00f3venes. \u201cTambi\u00e9n sabemos que este rejuvenecimiento epigen\u00e9tico garantiza que las c\u00e9lulas se comporten como c\u00e9lulas j\u00f3venes\u201d, dijo Oliver Br\u00fcstle, autor l\u00edder del estudio y director del Instituto de Neurobiolog\u00eda Reconstructiva del Hospital Universitario de Bonn, en un <a data-offer-url=\"https:\/\/www.uni-bonn.de\/de\/neues\/211-2026\" class=\"external-link\" data-event-click=\"{&quot;element&quot;:&quot;ExternalLink&quot;,&quot;outgoingURL&quot;:&quot;https:\/\/www.uni-bonn.de\/de\/neues\/211-2026&quot;}\" href=\"https:\/\/www.uni-bonn.de\/de\/neues\/211-2026\" rel=\"nofollow noopener\" target=\"_blank\">comunicado universitario.<\/a><\/p>\n<hr>\n<div class=\"ContentCardEmbedWrapper-hkvhYu kMYDit content-card-embed content-card-embed--stacked\" data-testid=\"ContentCardEmbedWrapper\" readability=\"20.769811320755\">\n<div class=\"ContentCardEmbedImage-bqahne fjmzkP content-card-embed__image\" data-testid=\"ContentCardEmbedImage\"><span class=\"SpanWrapper-kFnjvc eKnjjD responsive-asset\"><picture class=\"ResponsiveImagePicture-jKunQM gjCCFj responsive-image\"><img decoding=\"async\" alt=\"c\u00e9lulas envejecimiento 646052018\" loading=\"lazy\" class=\"ResponsiveImageContainer-dkeESL cQPiWi responsive-image__image\" srcset=\"https:\/\/media.es.wired.com\/photos\/69d547072ec3c6d0cad35dbb\/master\/w_120,c_limit\/c%C3%A9lulas%20envejecimiento%20646052018.jpg 120w, https:\/\/media.es.wired.com\/photos\/69d547072ec3c6d0cad35dbb\/master\/w_240,c_limit\/c%C3%A9lulas%20envejecimiento%20646052018.jpg 240w, https:\/\/media.es.wired.com\/photos\/69d547072ec3c6d0cad35dbb\/master\/w_320,c_limit\/c%C3%A9lulas%20envejecimiento%20646052018.jpg 320w, https:\/\/media.es.wired.com\/photos\/69d547072ec3c6d0cad35dbb\/master\/w_640,c_limit\/c%C3%A9lulas%20envejecimiento%20646052018.jpg 640w, https:\/\/media.es.wired.com\/photos\/69d547072ec3c6d0cad35dbb\/master\/w_768,c_limit\/c%C3%A9lulas%20envejecimiento%20646052018.jpg 768w\" sizes=\"100vw\" src=\"https:\/\/media.es.wired.com\/photos\/69d547072ec3c6d0cad35dbb\/master\/w_775%2Cc_limit\/c%25C3%25A9lulas%2520envejecimiento%2520646052018.jpg\"><\/picture><\/span><\/div>\n<div class=\"ContentCardEmbedInfo-buyHWH gWLOee\" readability=\"22.067924528302\">\n<div class=\"BaseText-fEwdHD ContentCardEmbedHed-kDKGDs iUENtL dlHXUJ content-card-embed__hed\" data-testid=\"ContentCardEmbedHed\"><a class=\"BaseLink-haTOKm ContentCardEmbedHedLink-iBZsco ILkR hhUFQU content-card-embed__hed-link link\" href=\"https:\/\/es.wired.com\/articulos\/por-primera-vez-esta-tecnica-para-rejuvenecer-celulas-envejecidas-sera-probada-en-humanos\" data-testid=\"ContentCardEmbedHedLink\">Por primera vez, esta t\u00e9cnica para rejuvenecer c\u00e9lulas envejecidas ser\u00e1 probada en humanos<\/a><\/div>\n<p>Est\u00e1 previsto que la <em>startup<\/em> Life Biosciences sea la primera en ensayar la reprogramaci\u00f3n celular parcial en humanos, una t\u00e9cnica que promete revertir el envejecimiento.<\/p>\n<\/div>\n<\/div>\n<hr>\n<h2>El debate sobre la identidad de las c\u00e9lulas rejuvenecidas<\/h2>\n<p>De acuerdo con el art\u00edculo publicado en <a data-offer-url=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70751\" class=\"external-link\" data-event-click=\"{&quot;element&quot;:&quot;ExternalLink&quot;,&quot;outgoingURL&quot;:&quot;https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70751&quot;}\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.70751\" rel=\"nofollow noopener\" target=\"_blank\"><em>Aging Cell<\/em><\/a>, en aproximadamente 50 d\u00edas el reloj de las c\u00e9lulas hab\u00eda retrocedido d\u00e9cadas. La Universidad de Bonn se\u00f1ala que los investigadores pudieron seguir la transformaci\u00f3n durante m\u00e1s de 100 d\u00edas. Una vez establecidas, las c\u00e9lulas tambi\u00e9n hab\u00edan perdido varias caracter\u00edsticas asociadas con la vejez.<\/p>\n<p>El reloj continu\u00f3 retrocediendo incluso cuando los cient\u00edficos redujeron de forma dr\u00e1stica la capacidad de las c\u00e9lulas para multiplicarse. Ello mantiene optimistas a los cient\u00edficos. El rejuvenecimiento aparente podr\u00eda no explicarse \u00fanicamente porque estuvieran produciendo c\u00e9lulas nuevas una y otra vez. El mecanismo que borra esas huellas de edad todav\u00eda no est\u00e1 claro.<\/p>\n<p>Si las c\u00e9lulas realmente est\u00e1n perdiendo parte de su edad biol\u00f3gica, el procedimiento permitir\u00eda estudiar c\u00f3mo borrar rasgos del envejecimiento sin devolver una c\u00e9lula por completo a un estado embrionario. A largo plazo, tambi\u00e9n podr\u00eda servir para producir c\u00e9lulas m\u00e1s j\u00f3venes a partir de pacientes mayores para investigaci\u00f3n o <a href=\"https:\/\/es.wired.com\/articulos\/la-revolucion-de-los-organos-que-se-reparan-solos-ya-comenzo\">medicina regenerativa<\/a>.<\/p>\n<p>Sin embargo, existe otra posibilidad: que las c\u00e9lulas no hayan rejuvenecido tanto como parece, sino que al cambiar de identidad hayan empezado a verse m\u00e1s j\u00f3venes ante ese reloj. Los propios autores reconocen esa limitaci\u00f3n. Una c\u00e9lula de la sangre y una c\u00e9lula del sistema nervioso no muestran exactamente las mismas se\u00f1ales asociadas con la edad, de modo que parte del retroceso podr\u00eda deberse a la <a href=\"https:\/\/es.wired.com\/articulos\/la-sorprendente-tecnica-que-convierte-al-cancer-en-su-propia-vacuna\">transformaci\u00f3n misma<\/a>. Las c\u00e9lulas reprogramadas, sin embargo, tambi\u00e9n perdieron otras caracter\u00edsticas relacionadas con la vejez.<\/p>\n<p>Todav\u00eda no se comprende por completo qu\u00e9 hace que una c\u00e9lula envejezca ni cu\u00e1l es la mejor manera de medirlo. La reprogramaci\u00f3n permite observar qu\u00e9 rastros de la vejez desaparecen cuando una c\u00e9lula adopta otra identidad, cu\u00e1les permanecen y cu\u00e1les cambian simplemente como consecuencia de esa transformaci\u00f3n.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cient\u00edficos en Alemania lograron que c\u00e9lulas tomadas&#46;&#46;&#46;<\/p>\n","protected":false},"author":1,"featured_media":479325,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[46],"tags":[],"class_list":["post-479324","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tecnologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.6 - 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