{"id":58106,"date":"2026-03-12T16:27:16","date_gmt":"2026-03-12T16:27:16","guid":{"rendered":"https:\/\/qpasa.com\/?p=107028"},"modified":"2026-03-12T16:27:16","modified_gmt":"2026-03-12T16:27:16","slug":"cientificos-en-japon-logran-eliminar-el-cromosoma-extra-asociado-al-sindrome-de-down-en-celulas-humanas","status":"publish","type":"post","link":"https:\/\/sarmiento24h.com\/?p=58106","title":{"rendered":"Cient\u00edficos en Jap\u00f3n logran eliminar el cromosoma extra asociado al s\u00edndrome de Down en c\u00e9lulas humanas"},"content":{"rendered":"
<\/div>\n

Un equipo de cient\u00edficos en Jap\u00f3n ha logrado un avance que est\u00e1 llamando la atenci\u00f3n de la comunidad cient\u00edfica internacional. En experimentos realizados en laboratorio, los investigadores consiguieron eliminar el cromosoma adicional asociado al s\u00edndrome de Down en c\u00e9lulas humanas.<\/p>\n

El resultado ha generado inter\u00e9s porque demuestra algo que durante d\u00e9cadas se consider\u00f3 extremadamente complejo. En condiciones de laboratorio, Jap\u00f3n elimina cromosoma extra<\/strong> en c\u00e9lulas con trisom\u00eda 21 mediante herramientas modernas de edici\u00f3n gen\u00e9tica.<\/p>\n

El estudio fue publicado en la revista cient\u00edfica PNAS Nexus<\/em> y se centr\u00f3 en investigar si era posible corregir la anomal\u00eda gen\u00e9tica responsable del s\u00edndrome de Down.<\/p>\n

El s\u00edndrome de Down ocurre cuando una persona tiene tres copias del cromosoma 21 en lugar de dos. Esta condici\u00f3n se conoce como trisom\u00eda 21<\/strong> y modifica la actividad de numerosos genes.<\/p>\n

En la investigaci\u00f3n japonesa, los cient\u00edficos utilizaron la herramienta de edici\u00f3n gen\u00e9tica CRISPR-Cas9<\/strong>, que permite identificar y cortar regiones espec\u00edficas del ADN.<\/p>\n

Mediante esta t\u00e9cnica, los investigadores lograron dirigir la edici\u00f3n gen\u00e9tica hacia el cromosoma adicional. En una parte de las c\u00e9lulas estudiadas fue posible eliminar esa copia extra.<\/p>\n

Este resultado permiti\u00f3 que algunas c\u00e9lulas recuperaran el n\u00famero habitual de cromosomas.<\/p>\n

El trabajo se realiz\u00f3 con c\u00e9lulas humanas cultivadas en laboratorio. Los cient\u00edficos aplicaron una estrategia de edici\u00f3n gen\u00e9tica dise\u00f1ada para identificar el cromosoma adicional y eliminarlo de manera selectiva.<\/p>\n

Cuando el proceso funcion\u00f3, las c\u00e9lulas que originalmente ten\u00edan trisom\u00eda 21 volvieron a presentar dos copias del cromosoma 21.<\/p>\n

Adem\u00e1s, los investigadores observaron que varias funciones celulares comenzaron a comportarse de forma m\u00e1s cercana a la de c\u00e9lulas sin trisom\u00eda.<\/p>\n

– Patrocinado –<\/span>
\n
\n<\/ins>\n<\/p>\n

Entre los cambios observados se encontraron mejoras en la actividad gen\u00e9tica, en el crecimiento celular y en la respuesta frente al estr\u00e9s oxidativo.<\/p>\n

Un avance relevante para la medicina gen\u00e9tica<\/h2>\n

El hecho de que Jap\u00f3n elimina cromosoma extra<\/strong> en c\u00e9lulas humanas demuestra que la correcci\u00f3n de anomal\u00edas cromos\u00f3micas podr\u00eda ser biol\u00f3gicamente posible.<\/p>\n

Para los investigadores, el estudio representa una prueba de concepto que abre nuevas l\u00edneas de investigaci\u00f3n en gen\u00e9tica, biolog\u00eda celular y medicina del futuro.<\/p>\n

Durante d\u00e9cadas, los cient\u00edficos han intentado comprender c\u00f3mo intervenir directamente en anomal\u00edas cromos\u00f3micas completas. Este trabajo sugiere que las herramientas de edici\u00f3n gen\u00e9tica podr\u00edan acercar ese objetivo.<\/p>\n

Por qu\u00e9 todav\u00eda no es un tratamiento<\/h2>\n

Aunque el avance es importante, los cient\u00edficos subrayan que el estudio se encuentra en una etapa temprana.<\/p>\n

Los experimentos se realizaron \u00fanicamente en c\u00e9lulas cultivadas en laboratorio. A\u00fan se requieren muchos estudios antes de pensar en aplicaciones m\u00e9dicas.<\/p>\n

Entre los retos que quedan por resolver est\u00e1 asegurar que la edici\u00f3n gen\u00e9tica act\u00fae \u00fanicamente sobre el cromosoma objetivo sin afectar otras partes del ADN.<\/p>\n

Tambi\u00e9n ser\u00e1 necesario desarrollar m\u00e9todos seguros para aplicar estas t\u00e9cnicas en tejidos humanos.<\/p>\n

– Patrocinado –<\/span>
\n
\n<\/ins>\n<\/p>\n

Por esta raz\u00f3n, el hallazgo se considera un avance cient\u00edfico importante, pero no un tratamiento disponible en la actualidad.<\/p>\n

Un nuevo camino para la investigaci\u00f3n<\/h2>\n

El s\u00edndrome de Down es la condici\u00f3n cromos\u00f3mica m\u00e1s frecuente en el mundo y afecta a millones de personas.<\/p>\n

Durante muchos a\u00f1os, la investigaci\u00f3n m\u00e9dica se ha centrado principalmente en mejorar la calidad de vida y el acceso a atenci\u00f3n especializada.<\/p>\n

El estudio japon\u00e9s introduce una nueva l\u00ednea de exploraci\u00f3n cient\u00edfica. En lugar de tratar \u00fanicamente las manifestaciones de la condici\u00f3n, algunos investigadores comienzan a analizar si en el futuro ser\u00e1 posible intervenir directamente en su base gen\u00e9tica.<\/p>\n

Aunque a\u00fan queda camino por recorrer, el estudio demuestra que la ciencia contin\u00faa ampliando las posibilidades de la medicina gen\u00e9tica.<\/p>\n","protected":false},"excerpt":{"rendered":"

Un equipo de cient\u00edficos en Jap\u00f3n ha...<\/p>\n","protected":false},"author":1,"featured_media":58107,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[59,64],"tags":[],"class_list":["post-58106","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad","category-salud"],"yoast_head":"\nCient\u00edficos en Jap\u00f3n logran eliminar el cromosoma extra asociado al s\u00edndrome de Down en c\u00e9lulas humanas - Sarmiento24h<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sarmiento24h.com\/?p=58106\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cient\u00edficos en Jap\u00f3n logran eliminar el cromosoma extra asociado al s\u00edndrome de Down en c\u00e9lulas humanas - 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